I can't really comment on the readings as in lots of cases other bloods are also pointers for certain things and I expect there are allsorts of reasons why certain readings can go higher. I expect your consultant might want to run a repeat test of the bloods to make sure that the readings are as your GP received and take things from there. Unfortunately I've never found out what is considered alarmingly high with regards to certain elements of the LFTs as mine were over double what they are currently were back in 2010. Although a positive correlation between MPV and fasting plasma glucose (FPG) levels has been reported, the correlation between MPV and postprandial glucose levels remains unclear. If you look at the PBC Foundations binder that members get sent or you can see it online if you are a member, there is a mention of markers of PBC.Īre you on any new medications currently as certain medications can all alter the LFTs (liver function test). Mean platelet volume (MPV) reflects platelet activity, and high MPV is associated with thrombogenic activation and increased cardiovascular disease risk. I know it is said that there are other factors for progression of PBC and the bilirubin is one of them. You can apparently have high cholesterol even in PBC as people who are otherwise healthy do too. I know mine was said to be slightly high during 2010 but nothing has ever been said since. I know pre-diagnosis it can be normal for cholesterol to be found to be raised due to bile being required to aid digestion of fats, bile that we are compromised with in PBC. o HDL-C (High Density Lipoprotein Cholesterol) is. As non-HDL-C, erythrocytes, and platelets all impact cardiovascular disease risk, there is a need for advancing understanding of the underlying interactions that govern levels of these three blood components.Well my ALP and also the AST are still what is known as abnormal, have been since I started itching early 2010 and was diagnosed with PBC Dec 2010 and started urso. However, elevated cholesterol levels have been associated with increased risk of coronary heart disease. These associations persisted in a sensitivity analysis excluding several conditions that affect erythrocyte/platelet and/or serum cholesterol levels, and were also noted in an independent analysis of 5,318 participants from NHANES 2007–2008. The magnitude of the relationship was most marked for platelets, with lowest versus highest non-HDL-C quartile subjects having geometric mean platelet counts of 258,000/μl versus 281,000/μl, respectively (adjusted model, P < 0.001 for trend). In linear regression analyses, serum non-high density lipoprotein-cholesterol (non-HDL-C) was positively associated with mean erythrocyte number, hematocrit, hemoglobin concentration, platelet count, and platelet crit independently of age, gender, race/ethnicity, smoking, body mass index, serum folate, and C-reactive protein. We examined the relationship between serum cholesterol and circulating erythrocyte/platelet indices in 4,469 adult participants of the National Health and Nutrition Examination Survey (NHANES) 2005–2006. Erythrocytes and platelets, anucleate cells relegated to nonspecific diffusional exchange of cholesterol with serum, have been proposed to have a distinct relationship to cholesterol from leukocytes. Whereas dyslipidemia has been associated with leukocytosis, the relationship between serum cholesterol and other hematopoietic lineages is poorly defined.
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